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Wnt/β-catenin通路抑制剂PNU-74654|PNU-74654|113906-27-7|Adamas life||BR|25mg
  • 探索价:
    (会员请登录查看专享价!)
  • 市场价:
    1360.00
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  • 探索编号:
    013653149
  • 原始编号:
    Y3307479B
  • 分子式:
    C19H16N2O3
  • MDL号:
  • CAS号:
    113906-27-7
  • 品牌:
    Adamas life
  • 分子量:
    320.34
  • 等级:
    BR
  • 参数/指标:
  • 规格:
    100ml
  • 货期:
    现货(工作日当天发货)
  • 库存:
  • 支付方式:
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基本信息
  • Wnt/β-catenin通路抑制剂PNU-74654
  • 苯甲酸;2-苯氧基-,2-[(5-甲基-2-呋喃基)亚甲基]酰胺
  • PNU-74654
  • Benzoic acid;2-phenoxy-,2-[(5-methyl-2-furanyl)methylene]hydrazide
  • Solid
  • -20℃, 3 years; 2-8°C, 2 years.
生物活性
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell.
体外研究 (In Vitro)
PNU-74654 binds to β-catenin with a KD of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot[2]. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability[1].
产品参数
CAS号
113906-27-7
分子式
C19H16N2O3
分子量
320.34
活性/IC50
Target Value
IC50 129.8 μM (Wnt/β-catenin, NCI-H295 cell)
存储条件
  • Powder
    -20°C 3 years
    2-8°C 2 years
  • In solvent
    -80°C 6 months
    -20°C 1 month
  • 溶解度
    DMSO
    ≥ 30 mg/mL (93.65 mM)
    制备储备液
    1 mg 5 mg 10 mg
    1 mM 3.1217 mL 15.6084 mL 31.2168 mL
    5 mM 0.6243 mL 3.1217 mL 6.2434 mL
    10 mM 0.3122 mL 1.5608 mL 3.1217 mL
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