危险化学品
省份
城市
区县
基本信息
- 2-甲基咪唑
- 2-甲基-1,3-氮杂茂;2-甲基-1H-咪唑;2-甲基咪唑;2-甲基甘噁啉;2-甲基甘啉
- 2-Methylimidazole
- 2-Methyl-1h-Imidazol;2-Methyl-Imidazol;p-Oxal-Methyline
- 267-268 °C
- 142-143 °C
- White to Light Yellow Powder or Solid or chunks
产品参数
CAS号
693-98-1
分子式
C4H6N2
分子量
82.1
细胞效力(Cellular Effect)
体外研究(In Vitro)
The target of rapamycin proteins regulate various cellular processes including autophagy, which may play a protective role in certain neurodegenerative and infectious diseases. Here we show that a primary small-molecule screen in yeast yields novel small-molecule modulators of mammalian autophagy. We first identified new small-molecule enhancers (SMER) and inhibitors (SMIR) of the cytostatic effects of rapamycin in Saccharomyces cerevisiae. Three SMERs induced autophagy independently of rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. These SMERs, which seem to act either independently or downstream of the target of rapamycin, attenuated mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential. We also screened structural analogs of these SMERs and identified additional candidate drugs that enhanced autophagy substrate clearance. Thus, we have demonstrated proof of principle for a new approach for discovery of small-molecule modulators of mammalian autophagy.
体内研究(In Vivo)
The target of rapamycin proteins regulate various cellular processes including autophagy, which may play a protective role in certain neurodegenerative and infectious diseases. Here we show that a primary small-molecule screen in yeast yields novel small-molecule modulators of mammalian autophagy. We first identified new small-molecule enhancers (SMER) and inhibitors (SMIR) of the cytostatic effects of rapamycin in Saccharomyces cerevisiae. Three SMERs induced autophagy independently of rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively.
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3、仅可用于工业或者科研等非医疗目的。买卖双方确认：依照中国法律法规之规定，我们的任何产品仅可用于工业或者科研等非医疗目的，不得直接或间接将产品用于临床诊断或其他未经许可的临床医疗用途。我们特此明示提醒：您应严格恪守上述规定，不得超越正常的科研或教学目的而违规使用产品，否则由此造成的一切后果均应由您承担；若我们因此遭受任何损失的，您也应负责对我们做出赔偿。
1、因厂家会在没有任何提前通知的情况下更改产品价格、包装、产地或者一些附件，若出现价格异常请以厂家官网价格为准，本司不能确保客户收到的货物与商城图片、产地、附件说明完全一致，只能确保为原厂正货！并且保证与当时市场上同样主流新品一致。若本商城没有及时更新，请大家谅解！
2、商品信息标注“易制毒”、“易涉毒”、“管制品”的商品，仅限非云南地区使用；如购买并发往云南地区使用的，责任自负。
3、仅可用于工业或者科研等非医疗目的。买卖双方确认：依照中国法律法规之规定，我们的任何产品仅可用于工业或者科研等非医疗目的，不得直接或间接将产品用于临床诊断或其他未经许可的临床医疗用途。我们特此明示提醒：您应严格恪守上述规定，不得超越正常的科研或教学目的而违规使用产品，否则由此造成的一切后果均应由您承担；若我们因此遭受任何损失的，您也应负责对我们做出赔偿。
